Effect of prophylactic laser iridotomy on corneal endothelial cell density over 3 years in primary angle closure suspects
- 30 November 2012
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 97 (3), 258-261
- https://doi.org/10.1136/bjophthalmol-2012-302013
Abstract
Objective To assess the effect of prophylactic laser peripheral iridotomy (LPI) on corneal endothelial cell density (ECD) and morphology in primary angle closure suspects (PACS) over 3 years. Methods In this prospective cohort study, subjects underwent LPI in one eye, while the fellow eye was untreated. Specular microscopy was performed at baseline and after 1 and 3 years. Central corneal ECD and morphology of both eyes were assessed using non-contact specular microscopy (Konan SP-9000LC, Konan Inc, Hyogo, Japan). Results 230 subjects completed 3-year follow-up. The mean age was 62.5±8.0 years, and the majority of subjects were Chinese (92.3%) and women (75.4%). In eyes that underwent LPI, ECD was significantly lower at year 1 (2462.3, 95% CI 2414.5 to 2510.0, pConclusions In PACS eyes, there was decrease in ECD in LPI-treated and control eyes over 3 years, with no significant difference between groups.Keywords
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