Patients with Pulmonary Tuberculosis Develop a Strong Humoral Response against Methylated Heparin-Binding Hemagglutinin
- 1 September 2005
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 12 (9), 1135-8
- https://doi.org/10.1128/cdli.12.9.1135-1138.2005
Abstract
Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.Keywords
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