The Multifaceted Actions of PTHrP in Skeletal Metastasis
- 25 July 2012
- journal article
- review article
- Published by Taylor & Francis Ltd in Future Oncology
- Vol. 8 (7), 803-817
- https://doi.org/10.2217/fon.12.76
Abstract
PTHrP, identified during the elucidation of mediators of malignancy-induced hypercalcemia, plays numerous roles in normal physiology as well as pathological conditions. Recent data support direct functions of PTHrP in metastasis, particularly from tumors with strong bone tropism. Bone provides a unique metastatic environment because of mineralization and the diverse cell populations in the bone marrow. PTHrP is a key regulator of tumor–bone interactions and regulates cells in the bone microenvironment through proliferative and prosurvival activities that prime the ‘seed’ and the ‘soil’ of the metastatic lesion. This review highlights recent findings regarding the role of PTHrP in skeletal metastasis, including direct actions in tumor cells, as well as alterations in the bone microenvironment and future perspectives involving the potential roles of PTHrP in the premetastatic niche, and tumor dormancy.This publication has 108 references indexed in Scilit:
- Biographical Sketch: Fuller Albright, MD 1900-1969Clinical Orthopaedics & Related Research, 2011
- Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292Clinical & Experimental Metastasis, 2011
- A 7-day continuous infusion of PTH or PTHrP suppresses bone formation and uncouples bone turnoverJournal of Bone and Mineral Research, 2011
- The seed and soil hypothesis revisited—The role of tumor‐stroma interactions in metastasis to different organsInternational Journal of Cancer, 2011
- The amazing osteocyteJournal of Bone and Mineral Research, 2010
- PTHrP promotes colon cancer cell migration and invasion in an integrin α6β4-dependent manner through activation of Rac1Cancer Letters, 2010
- Gr-1+CD11b+ myeloid-derived suppressor cells: Formidable partners in tumor metastasisJournal of Bone and Mineral Research, 2010
- Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesisJournal of Bone and Mineral Research, 2010
- PTH and PTHrP signaling in osteoblastsCellular Signalling, 2009
- PTHrP increases xenograft growth and promotes integrin α6β4 expression and Akt activation in colon cancerCancer Letters, 2007