Automated Segmentation of Neural Canal Opening and Optic Cup in 3D Spectral Optical Coherence Tomography Volumes of the Optic Nerve Head
Open Access
- 1 November 2010
- journal article
- glaucoma
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Ophthalmology & Visual Science
- Vol. 51 (11), 5708-5717
- https://doi.org/10.1167/iovs.09-4838
Abstract
Purpose.: To develop an automated approach for segmenting the neural canal opening (NCO) and cup at the level of the retinal pigment epithelium (RPE)/Bruch's membrane (BM) complex in spectral-domain optical coherence tomography (SD-OCT) volumes. To investigate the correspondence and discrepancy between the NCO-based metrics and the clinical disc margin on fundus photographs of glaucoma subjects. Methods.: SD-OCT scans and corresponding stereo fundus photographs of the optic nerve head were obtained from 68 eyes of 34 patients with glaucoma or glaucoma suspicion. Manual planimetry was performed by three glaucoma experts to delineate a reference standard (RS) for cup and disc margins from the images. An automated graph-theoretic approach was used to identify the NCO and cup. NCO-based metrics were compared with the RS. Results.: Compared with the RS disc margin, the authors found mean unsigned and signed border differences of 2.81 ± 1.48 pixels (0.084 ± 0.044 mm) and −0.99 ± 2.02 pixels (−0.030 ± 0.061 mm), respectively, for NCO segmentation. The correlations of the linear cup-to-disc (NCO) area ratio, disc (NCO) area, rim area, and cup area of the algorithm with the RS were 0.85, 0.77, 0.69, and 0.83, respectively. Conclusions.: In most eyes, the NCO-based 2D metrics, as estimated by the novel automated graph-theoretic approach to segment the NCO and cup at the level of the RPE/BM complex in SD-OCT volumes, correlate well with RS. However, a small discrepancy exists in NCO-based anatomic structures and the clinical disc margin of the RS in some eyes.This publication has 16 references indexed in Scilit:
- Automated Segmentation of the Cup and Rim from Spectral Domain OCT of the Optic Nerve HeadInvestigative Ophthalmology & Visual Science, 2009
- 3-D Histomorphometry of the Normal and Early Glaucomatous Monkey Optic Nerve Head: Lamina Cribrosa and Peripapillary Scleral Position and ThicknessInvestigative Ophthalmology & Visual Science, 2007
- Three-Dimensional Histomorphometry of the Normal and Early Glaucomatous Monkey Optic Nerve Head: Neural Canal and Subarachnoid Space ArchitectureInvestigative Ophthalmology & Visual Science, 2007
- Automated Segmentation of the Optic Disc from Stereo Color Photographs Using Physiologically Plausible FeaturesInvestigative Ophthalmology & Visual Science, 2007
- Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetricBMC Neuroscience, 2006
- Rate of Optic Disc Cup Progression in Treated Primary Open-Angle GlaucomaJournal of Glaucoma, 2003
- Deformation of the Lamina Cribrosa and Anterior Scleral Canal Wall in Early Experimental GlaucomaInvestigative Ophthalmology & Visual Science, 2003
- Optic Disc and Visual Field Changes in a Prospective Longitudinal Study of Patients With GlaucomaAmerican Journal of Ophthalmology, 2001
- Quantification of Nerve Fiber Layer Thickness in Normal and Glaucomatous Eyes Using Optical Coherence TomographyAmerican Journal of Ophthalmology, 1995
- Intraobserver and Interobserver Agreement in Measurement of Optic Disc CharacteristicsOphthalmology, 1988