What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
- 26 September 2006
- journal article
- review article
- Published by Wiley in International Journal of Cancer
- Vol. 119 (10), 2247-2254
- https://doi.org/10.1002/ijc.22153
Abstract
Substantial evidence supports a functional role for cyclooxygenase‐ and lipoxygenase‐catalyzed arachidonic and linoleic acid metabolism in cancer development. Genetic intervention studies firmly established cause‐effect relations for cyclooxygenase‐2, but cyclooxygenase‐1 may also be involved. In addition, pharmacologic cyclooxygenase inhibition was found to suppress carcinogenesis in both experimental mouse models and several cancers in humans. Arachidonic acid‐derived eicosanoid or linoleic acid‐derived hydro[peroxy]fatty acid signaling are likely to be involved impacting fundamental biologic phenomina as diverse as cell growth, cell survival, angiogenesis, cell invasion, metastatic potential and immunomodulation. However, long chain unsaturated fatty acid oxidation reactions indicate antipodal functions of distinct lipoxygenase isoforms in carcinogenesis, i.e., the 5‐ and platelet‐type 12‐lipoxygenase exhibit procarcinogenic activities, while 15‐lipoxygenase‐1 and 15‐lipoxygenase‐2 may suppress carcinogenesis.This publication has 91 references indexed in Scilit:
- Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancerJournal of Clinical Pathology, 2006
- Changes in gene expression contribute to cancer prevention by COX inhibitorsProgress in Lipid Research, 2006
- Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunitiesJCI Insight, 2005
- LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathwaysBiochemical and Biophysical Research Communications, 2005
- COX-2: A Molecular Target for Colorectal Cancer PreventionJournal of Clinical Oncology, 2005
- The eicosanoid cascade: possible role in gliomas and meningiomasJournal of Clinical Pathology, 2004
- Prostanoid receptor signaling relevant to tumor growth and angiogenesisTrends in Pharmacological Sciences, 2003
- Inflammation and cancerNature, 2002
- The Role of Cyclooxygenase and Lipoxygenase in Cancer ChemopreventionDrug Metabolism and Drug Interactions, 2000
- The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous PolyposisThe New England Journal of Medicine, 2000