Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF TIR1 in Mediating Auxin Response
- 18 May 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 292 (5520), 1379-1382
- https://doi.org/10.1126/science.1059776
Abstract
The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis . Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCF TIR1 . Furthermore, we found that the COP9 signalosome and SCF TIR1 interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCF TIR1 . Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase–mediated responses.This publication has 24 references indexed in Scilit:
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