Progression of Chronic Hepatitis C to Liver Fibrosis and Cirrhosis in Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus
Open Access
- 15 February 2003
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 36 (4), 491-498
- https://doi.org/10.1086/367643
Abstract
To evaluate the factors associated with the evolution of chronic hepatitis C in human immunodeficiency virus (HIV)—infected patients, a cross-sectional analysis of 41 HIV-infected patients with chronic hepatitis C (known as “HIV-HCV [hepatitis C virus]—coinfected patients”) and a control group of patients with chronic hepatitis C who did not have HIV infection (known as “non-HIV-infected patients”) was performed. The association of histological variables with demographic parameters, HCV load and genotype, HIV load, CD4+ T cell count, and response to highly active antiretroviral therapy (HAART) was evaluated. HIV-HCV—coinfected patients showed a significantly higher HCV load, more-advanced fibrosis, and a higher liver fibrosis progression rate (FPR) than did non—HIV-infected patients. A high HCV load and a low CD4+ T cell count were associated with a higher FPR. The immune response induced by HAART did not influence this progression. In conclusion, HIV-HCV—infected patients, mainly such patients with a high HCV load and an immunodepressed state, have a higher FPR. An independent effect of the immune response to HAART was not evident.This publication has 34 references indexed in Scilit:
- Factors related to the chronicity and evolution of hepatitis C infection in patients co-infected by the human immunodeficiency virusClinical Microbiology & Infection, 2002
- Evolution of Coinfection with Human Immunodeficiency Virus and Hepatitis C Virus in Patients Treated with Highly Active Antiretroviral TherapyClinical Infectious Diseases, 2001
- Hepatitis C Virus/Human Immunodeficiency Virus Coinfection: Clinical Management IssuesClinical Infectious Diseases, 2000
- Relationship of hepatitis C viremia to HIV state and to infection by specific hepatitis C genotypesLiver International, 1999
- Antiretroviral therapy for HIV infection in 1997. Updated recommendations of the International AIDS Society-USA panelJAMA, 1997
- Human immunodeficiency virus infection modified the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosisJournal of Hepatology, 1997
- An algorithm for the grading of activity in chronic hepatitis CHepatology, 1996
- Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired Hepatitis CEuropean Journal of Clinical Microbiology & Infectious Diseases, 1995
- Classification of chronic viral hepatitis: a need for reassessmentJournal of Hepatology, 1991
- Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitisHepatology, 1981