Activation of BPV-1 replication in vitro by the transcription factor E2
- 1 October 1991
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 353 (6345), 628-632
- https://doi.org/10.1038/353628a0
Abstract
Soluble extracts from uninfected murine cells supplemented with purified viral E1 and E2 proteins support the replication of exogenously added papilloma virus DNA. The E2 transactivator stimulates the binding of the E1 replication protein to the minimal origin of replication and activates DNA replication. These results support the concept that transcription factors have a direct role in the initiation of DNA replication in eukaryotes by participating in the assembly of a complex at the origin of replication.Keywords
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