Cell totipotency: molecular features, induction, and maintenance
Open Access
- 15 February 2015
- journal article
- research article
- Published by Oxford University Press (OUP) in National Science Review
- Vol. 2 (2), 217-225
- https://doi.org/10.1093/nsr/nwv009
Abstract
In mammals, pluripotent stem cells can give rise to every cell type of embryonic lineage, and hold great potential in regenerative medicine and disease modeling. Guided by the mechanism underlying pluripotency, pluripotent stem cells have been successfully induced through manipulating the transcriptional and epigenetic networks of various differentiated cell types. However, the factors that confer totipotency, the ability to give rise to cells in both embryonic and extra-embryonic lineages still remain poorly understood. It is currently unknown whether totipotency can be induced and maintained in vitro. In this review, we summarize the current progress in the field, with the aim of providing a foundation for understanding the mechanisms that regulate totipotency.Keywords
This publication has 96 references indexed in Scilit:
- Role of Tet proteins in enhancer activity and telomere elongationGenes & Development, 2014
- Chromatin features and the epigenetic regulation of pluripotency states in ESCsDevelopment, 2014
- Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotesNature Structural & Molecular Biology, 2014
- Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidationCell Research, 2012
- Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosineProceedings of the National Academy of Sciences of the United States of America, 2011
- Viable offspring derived from fetal and adult mammalian cellsNature, 1997
- Regulation of zygotic gene activation in the mouseBioEssays, 1993
- Effects of Extracellular Matrices and Growth Factors on the Development of Isolated Porcine Blastomeres1Biology of Reproduction, 1991
- Amounts, synthesis, and some properties of intracisternal A particle-related RNA in early mouse embryos.Proceedings of the National Academy of Sciences of the United States of America, 1984
- Postimplantation development of blastomeres isolated from 4- and 8-cell mouse eggsDevelopment, 1976