Enhanced composite electrospun nanofiber scaffolds for use in drug delivery
- 25 September 2008
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Drug Delivery
- Vol. 5 (10), 1093-1106
- https://doi.org/10.1517/17425247.5.10.1093
Abstract
The utility of nanofibrous electrospun composite scaffolds has greatly expanded over the last decade, so that they now serve as viable drug delivery vehicles for a host of different biomedical applications. The material properties of electrospun scaffolds are extremely advantageous for drug delivery, in which site-specificity and lower overall medicinal dosages lead to a potential industry-altering mechanism of delivering therapeutics. Different drugs used to predominantly treat infections and cancers can easily be incorporated and released at therapeutic dosages. Further, the inherent high porosity of these electrospun scaffolds allows for a more precisely controlled degradation which is tunable by polymer composition and fiber morphology, leading to sustained drug release. This review examines the current research and breakthrough discoveries that have elevated electrospun scaffolds to a cutting-edge technology that will dramatically alter the landscape of drug delivery.Keywords
This publication has 100 references indexed in Scilit:
- Transient elastic support for vein grafts using a constricting microfibrillar polymer wrapBiomaterials, 2008
- Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineeringBiomaterials, 2008
- The biodegradability of electrospun Dextran/PLGA scaffold in a fibroblast/macrophage co-cultureBiomaterials, 2008
- The design of electrospun PLLA nanofiber scaffolds compatible with serum-free growth of primary motor and sensory neuronsActa Biomaterialia, 2008
- Generating Elastic, Biodegradable Polyurethane/Poly(lactide-co-glycolide) Fibrous Sheets with Controlled Antibiotic Release via Two-Stream ElectrospinningBiomacromolecules, 2008
- Functional electrospun nanofibrous scaffolds for biomedical applicationsAdvanced Drug Delivery Reviews, 2007
- Functionalization of poly(L‐lactide) nanofibrous scaffolds with bioactive collagen moleculesJournal of Biomedical Materials Research Part A, 2007
- In situ growth of hydroxyapatite within electrospun poly(DL‐lactide) fibersJournal of Biomedical Materials Research Part A, 2007
- Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineeringJournal of Biomechanics, 2006
- In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesionsJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2006