Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities
- 4 June 2008
- journal article
- Published by Springer Science and Business Media LLC in Journal of Natural Medicines
- Vol. 62 (4), 470-472
- https://doi.org/10.1007/s11418-008-0259-7
Abstract
Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.Keywords
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