Prognostic Value of Olfactory Bulb Volume Measurement for Recovery in Postinfectious and Posttraumatic Olfactory Loss
- 5 September 2012
- journal article
- research article
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 147 (6), 1136-1141
- https://doi.org/10.1177/0194599812459704
Abstract
Several prognostic factors influencing the recovery from olfactory dysfunction have been described. The aim of this study was to investigate whether olfactory bulb volume could be used as a new predictor of olfactory recovery in postinfectious and posttraumatic olfactory loss. Cohort study; Level of evidence, 4. Tertiary university clinic, department of otolaryngology. A cohort of 60 patients with postinfectious (n = 28) and posttraumatic olfactory loss (n = 32) was investigated. Assessment of olfactory function was performed using orthonasal (Sniffin’ Sticks test) and retronasal psychophysical olfactory tests, at the time of the diagnosis (t1) and 15 months later (t2). All patients were examined on 3 tesla magnetic resonance imaging, and the olfactory bulbs volume was assessed using planimetric contouring at the time of the diagnosis (t1). Recovery rate was 25% in patients with posttraumatic olfactory loss and 36% in patients with postinfectious olfactory loss. There was a correlation between both orthonasal and retronasal olfactory testing and the initial measurement of the total olfactory bulb volume. In addition, we observed a significant correlation between changes in olfactory functions and initial measurement of the total olfactory bulb volume, with larger volumes relating to higher improvement of olfactory function. Finally, we found that none of the patients with a total olfactory bulb volume of 40 mm3 or less exhibited recovery of olfactory function. Olfactory bulb volume seems to be a predictor of olfactory recovery in patients with postinfectious and posttraumatic olfactory loss.Keywords
This publication has 30 references indexed in Scilit:
- Health‐related and specific olfaction‐related quality of life in patients with chronic functional anosmia or severe hyposmiaThe Laryngoscope, 2011
- The Chemical Senses and Nutrition in Older AdultsJournal of Nutrition For the Elderly, 2008
- An updated review of clinical olfactionCurrent Opinion in Otolaryngology & Head and Neck Surgery, 2006
- Olfactory disorders and their consequences for quality of lifeActa Oto-Laryngologica, 2005
- Chronic sinusitis and olfactory dysfunctionOtolaryngologic Clinics of North America, 2004
- A Study on the Frequency of Olfactory DysfunctionThe Laryngoscope, 2004
- Olfactory dysfunction and daily lifeEuropean Archives of Oto-Rhino-Laryngology, 2004
- Impact of Olfactory Impairment on Quality of Life and DisabilityJAMA Otolaryngology–Head & Neck Surgery, 2001
- The Diagnosis of a Conductive Olfactory LossThe Laryngoscope, 2001
- Disorders in Taste and SmellMedical Clinics of North America, 1991