Newcastle disease
Top Cited Papers
- 15 June 2011
- journal article
- review article
- Published by SAGE Publications in Journal of Veterinary Diagnostic Investigation
- Vol. 23 (4), 637-656
- https://doi.org/10.1177/1040638711407887
Abstract
Newcastle disease (ND) remains a constant threat to the poultry industry and is a limiting disease for poultry producers worldwide. The variety of clinical presentations and the emergence and spread of new genetic variants make recognition and diagnosis challenging. The current review details the pertinent features of the clinicopathologic disease in the main susceptible species, including chicken, turkey, duck, goose, pigeon, and other birds such as cormorants, psittacines, and canaries. Furthermore, the available and emerging laboratory diagnostic methodologies for the detection and typing of the virus are reviewed, including traditional techniques such as virus isolation and immunohistochemistry as well as rapid procedures based on molecular tools, such as real-time polymerase chain reaction, gene sequencing, and microarrays. The relevant genetic variability of ND viruses probably represents the major limitation in the validation and application of the current, advanced diagnostic molecular techniques. This underscores the importance of a multidisciplinary and comprehensive diagnostic approach, which should include, next to the new generation assays of the genomic era, the more traditional techniques such as histopathology, immunohistochemistry, and virus isolation.Keywords
This publication has 94 references indexed in Scilit:
- Evolutionary Changes Affecting Rapid Identification of 2008 Newcastle Disease Viruses Isolated from Double-Crested CormorantsJournal of Clinical Microbiology, 2010
- Newcastle disease: Evolution of genotypes and the related diagnostic challengesInfection, Genetics and Evolution, 2010
- False-Negative Results of a Validated Real-Time PCR Protocol for Diagnosis of Newcastle Disease Due to Genetic Variability of the Matrix GeneJournal of Clinical Microbiology, 2009
- Phylogenetic Diversity among Low-Virulence Newcastle Disease Viruses from Waterfowl and Shorebirds and Comparison of Genotype Distributions to Those of Poultry-Origin IsolatesJournal of Virology, 2007
- Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implicationsVirus Research, 2006
- Excretion of pathogenic Newcastle disease virus by double‐crested cormorants (Phalacrocorax auritus) in absence of mortality or clinical signs of diseaseAvian Pathology, 1998
- Newcastle disease virus: Detection and characterization by PCR of recent German isolates differing in pathogenicityAvian Pathology, 1998
- Differentiation of virulent and non‐virulent strains of Newcastle disease virus within 24 hours by polymerase chain reactionAvian Pathology, 1997
- The pathology of infection of chickens with the lentogenic V4 strain of Newcastle disease virusAvian Pathology, 1990
- Thermostability of Newcastle disease virus strains of different virulenceArchiv für die gesamte Virusforschung, 1975