Biochemical studies of normal and keratoconus corneas

Abstract

Keratoconus corneas are characterized by a reduced mechanical stability. The mechanical strength depends primarily on the collagen. In the present study the cross-linking pattern is analyzed because it is important for the mechanical properties; an analysis of the aminoacids of the collagen is included. Surprisingly, we did not find any change in the cross-linking pattern of collagen from keratoconus corneas compared to normal corneas. Neither did we find any difference in the composition of aminoacids of the collagens. Thus no alteration was found in the molecular structure which could explain the marked reduction in the mechanical stability of keratoconous corneas.