Chromosome-Encoded Ambler Class D β-Lactamase ofShewanella oneidensisas a Progenitor of Carbapenem-Hydrolyzing Oxacillinase
- 1 January 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (1), 348-51
- https://doi.org/10.1128/aac.48.1.348-351.2004
Abstract
A chromosome-encoded β-lactamase gene from aShewanella oneidensisreference strain was cloned and expressed inEscherichia coli. It encoded a carbapenem-hydrolyzing Ambler class D β-lactamase, OXA-54, that shared 92% amino acid identity with the plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 fromKlebsiella pneumoniae. This work suggests thatShewanellaspp. may produce the progenitor of oxacillinases compromising the efficacy of imipenem in clinically relevant gram-negative pathogens.Keywords
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