Oxacillinase-Mediated Resistance to Cefepime and Susceptibility to Ceftazidime inPseudomonas aeruginosa
Open Access
- 1 June 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (6), 1615-1620
- https://doi.org/10.1128/aac.45.6.1615-1620.2001
Abstract
Pseudomonas aeruginosaclinical isolate SOF-1 was resistant to cefepime and susceptible to ceftazidime. This resistance phenotype was explained by the expression of OXA-31, which shared 98% amino acid identity with a class D β-lactamase, OXA-1. Theoxa-31gene was located on a ca. 300-kb nonconjugative plasmid and on a class 1 integron. No additional efflux mechanism for cefepime was detected inP. aeruginosaSOF-1. Resistance to cefepime and susceptibility to ceftazidime inP. aeruginosawere conferred by OXA-1 as well.Keywords
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