Activity of Δ 8 - and Δ 9 -Tetrahydrocannabinol and Related Compounds in the Mouse
- 9 April 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3979), 165-167
- https://doi.org/10.1126/science.172.3979.165
Abstract
The 11-hydroxy metabolites of Δ8.- and Δ9-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Δ8- and Δ9-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussedKeywords
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