RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
- 4 November 2002
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 32 (4), 581-583
- https://doi.org/10.1038/ng1021
Abstract
RNASEL (encoding ribonuclease L) has recently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene. We determined that the RNASEL variant Arg462Gln has three times less enzymatic activity than the wildtype and is significantly associated with prostate cancer risk (P = 0.007). At least one copy of the mutated allele that causes this substitution is carried by nearly 60% of the men in our study. Men that are heterozygous with respect to the mutated allele have 50% greater risk of prostate cancer than non-carriers, and homozygotes have more than double the risk.Keywords
This publication has 12 references indexed in Scilit:
- A Novel Founder Mutation in the RNASEL Gene, 471delAAAG, Is Associated with Prostate Cancer in Ashkenazi JewsAmerican Journal of Human Genetics, 2002
- Analysis of the RNASEL Gene in Familial and Sporadic Prostate CancerAmerican Journal of Human Genetics, 2002
- Germline Alterations of the RNASEL Gene, a Candidate HPC1 Gene at 1q25, in Patients and Families with Prostate CancerAmerican Journal of Human Genetics, 2002
- Germline mutations in the ribonuclease L gene in families showing linkage with HPC1Nature Genetics, 2002
- Combined Analysis of Hereditary Prostate Cancer Linkage to 1q24-25: Results from 772 Hereditary Prostate Cancer Families from the International Consortium for Prostate Cancer GeneticsAmerican Journal of Human Genetics, 2000
- Linkage Analysis of Chromosome 1q Markers in 136 Prostate Cancer FamiliesAmerican Journal of Human Genetics, 1998
- Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase LThe EMBO Journal, 1997
- Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)Nucleic Acids Research, 1989
- CONCEPTUAL PROBLEMS IN THE DEFINITION AND INTERPRETATION OF ATTRIBUTABLE FRACTIONSAmerican Journal of Epidemiology, 1988
- pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.Proceedings of the National Academy of Sciences of the United States of America, 1978