Reconfiguration of DNA molecular arrays driven by information relay
- 28 July 2017
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 357 (6349)
- https://doi.org/10.1126/science.aan3377
Abstract
Relaying information on DNA tiles: Arrays of modular DNA units can relay information by transforming their internal shape in response to binding of DNA trigger strands. Song et al. synthesized rectangular arrays of double-stranded DNA (see the Perspective by Yang and Lin). Transient square configurations transform into two stable rectangular structures by pinching across a pair of opposing vertices. Binding of DNA trigger strands causes switching into the alternative stable configuration. The tiles thus create a cascade of transformations along a particular pathway, thereby transmitting information about where binding occurred. Science , this issue p. eaan3377 ; see also p. 352Keywords
Funding Information
- National Science Foundation (DMR–1654485)
- National Science Foundation (CMMI–1437301)
- Office of Naval Research (N00014-15-1-2707)
- National Natural Science Foundation of China (21605102)
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