Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells
Open Access
- 1 January 2013
- journal article
- Published by Scientific Research Publishing, Inc. in Journal of Biomaterials and Nanobiotechnology
- Vol. 04 (01), 53-63
- https://doi.org/10.4236/jbnb.2013.41008
Abstract
Nanoparticles are considered as powerful tools in nanotechnological applications. Due to their unique physicochemical properties, their interactions with different biological systems have been shown. Nanomaterials have been successfully used as coating materials or treatment and diagnosis tools. Nevertheless, toxic effects of nanoparticles in vitro and in vivo have also been reported. Here, we summarize the current state of knowledge on exposure routes, cellular uptake and toxicological activities of the commonly used nanoparticles. In this context, we discuss the mechanisms of toxicity of nanoparticles involving perturbation of redox milieu homeostasis and cellular signaling pathways.Keywords
This publication has 74 references indexed in Scilit:
- Subchronic inhalation toxicity of gold nanoparticlesParticle and Fibre Toxicology, 2011
- Tunable, Ultrasensitive pH‐Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living CellsAngewandte Chemie, 2011
- Nanoparticles Induce Changes of the Electrical Activity of Neuronal Networks on Microelectrode Array NeurochipsEnvironmental Health Perspectives, 2010
- The Influences of Cell Type and ZnO Nanoparticle Size on Immune Cell Cytotoxicity and Cytokine InductionNanoscale Research Letters, 2009
- DNA methylation and methyl-CpG binding proteins: developmental requirements and functionChromosoma, 2009
- Nanotechnology, nanotoxicology, and neuroscienceProgress in Neurobiology, 2009
- Effect of Nanoparticles on Protein Folding and FibrillogenesisInternational Journal of Molecular Sciences, 2009
- Alternative Modes of Binding of Recombinant Human Histone Deacetylase 8 to Colloidal Gold NanoparticlesJournal of Biomedical Nanotechnology, 2008
- Surface chemistry influences cancer killing effect of TiO2 nanoparticlesNanomedicine: Nanotechnology, Biology and Medicine, 2008
- Gold-Nanoparticle-Assisted Laser Perturbation of Chromatin Assembly Reveals Unusual Aspects of Nuclear Architecture within Living CellsBiophysical Journal, 2007