COVID-19 mRNA vaccine in pregnancy and newborn passive immunization: a case report
Open Access
- 29 October 2021
- journal article
- research article
- Published by Informa UK Limited in Future Science OA
- Vol. 8 (1), FSO761
- https://doi.org/10.2144/fsoa-2021-0043
Abstract
Aim: Evaluating the newborn passive immunization after maternal vaccination against SARS-COV-2. Case presentation: We present the case of a pregnant woman, with no prior history of COVID-19 infection, who got her second dose of mRNA vaccine against SARS-COV-2, 3 days before the start of her spontaneous labor. She was delivered by cesarean section after dynamical dystocia. Placental cord blood was retrieved immediately and sent to evaluate the titers of COVID-19 antibodies. Vaccine-generated antibodies were present in the umbilical cord with IgG spike >100 AU/ml. Conclusion: By reviewing the literature, vaccination seems to give hope about the potential protective effect of the maternal vaccination on her baby. Thus, pregnant women deserve a priority in the COVID-19 vaccination program. Lay Counseling pregnant patients about COVID-19 vaccine safety for her and her fetus is a common issue facing obstetricians. The WHO does not recommend the vaccination for pregnant women except for patients considered with unavoidable risk of high exposure. We present the case of a pregnant woman, with no prior history of COVID-19, who got her second dose of mRNA vaccine against SARS-COV-2, 3 days before the start of her spontaneous labor. Vaccine-generated antibodies were present in the umbilical cord. In conclusion, vaccination seems to give hope about the potential protective effect of the maternal vaccination on her baby.Keywords
This publication has 9 references indexed in Scilit:
- Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort studyAmerican Journal of Obstetrics and Gynecology, 2021
- COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variantsNature Communications, 2021
- Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case reportBMC Pediatrics, 2021
- COVID-19 vaccine response in pregnant and lactating women: a cohort studymedRxiv, 2021
- Are COVID-19 vaccines safe in pregnancy?Nature Reviews Immunology, 2021
- Pregnant women with SARS‐CoV‐2 infection are at higher risk of death and pneumonia: propensity score matched analysis of a nationwide prospective cohort (COV19Mx)Ultrasound in Obstetrics & Gynecology, 2020
- COVID‐19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmissionAustralian and New Zealand Journal of Obstetrics and Gynaecology, 2020
- The Impact of IgG Transplacental Transfer on Early Life ImmunityImmunoHorizons, 2018
- IgG Placental Transfer in Healthy and Pathological PregnanciesClinical and Developmental Immunology, 2011