Pregnane X receptor‐ and CYP3A4‐humanized mouse models and their applications
- 11 May 2011
- journal article
- review article
- Published by Wiley in British Journal of Pharmacology
- Vol. 163 (3), 461-468
- https://doi.org/10.1111/j.1476-5381.2010.01129.x
Abstract
Pregnane X receptor (PXR) is a pivotal nuclear receptor modulating xenobiotic metabolism primarily through its regulation of CYP3A4, the most important enzyme involved in drug metabolism in humans. Due to the marked species differences in ligand recognition by PXR, PXR-humanized (hPXR) mice, and mice expressing human PXR and CYP3A4 (Tg3A4/hPXR) were established. hPXR and Tg3A4/hPXR mice are valuable models for investigating the role of PXR in xenobiotic metabolism and toxicity, in lipid, bile acid and steroid hormone homeostasis, and in the control of inflammation.This publication has 51 references indexed in Scilit:
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