Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge
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Open Access
- 29 May 2019
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 11 (494)
- https://doi.org/10.1126/scitranslmed.aau9242
Abstract
Nipah virus is an emerging pathogen in the Paramyxoviridae family. Upon transmission of Nipah virus from its natural reservoir, Pteropus spp. fruit bats, to humans, it causes respiratory and neurological disease with a case-fatality rate about 70%. Human-to-human transmission has been observed during Nipah virus outbreaks in Bangladesh and India. A therapeutic treatment for Nipah virus disease is urgently needed. Here, we tested the efficacy of remdesivir (GS-5734), a broad-acting antiviral nucleotide prodrug, against Nipah virus Bangladesh genotype in African green monkeys. Animals were inoculated with a lethal dose of Nipah virus, and a once-daily intravenous remdesivir treatment was initiated 24 hours later and continued for 12 days. Mild respiratory signs were observed in two of four treated animals, whereas all control animals developed severe respiratory disease signs. In contrast to control animals, which all succumbed to the infection, all remsdesivir-treated animals survived the lethal challenge, indicating that remdesivir represents a promising antiviral treatment for Nipah virus infection.Keywords
Funding Information
- Centers for Disease Control and Prevention
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
This publication has 18 references indexed in Scilit:
- Nipah Virus InfectionJournal of Clinical Microbiology, 2018
- Favipiravir (T-705) protects against Nipah virus infection in the hamster modelScientific Reports, 2018
- Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronavirusesScience Translational Medicine, 2017
- GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and ParamyxovirusesScientific Reports, 2017
- First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus DiseaseThe Journal of Infectious Diseases, 2017
- Effective Chemical Inactivation of Ebola VirusEmerging Infectious Diseases, 2016
- Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeysNature, 2016
- Nipah Virus InfectionThe American Journal of Pathology, 2002
- Late presentation of Nipah virus encephalitis and kinetics of the humoral immune responseJournal of Neurology, Neurosurgery & Psychiatry, 2001
- Laboratory diagnosis of Nipahand Hendra virus infectionsMicrobes and Infection, 2001