First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease
Open Access
- 9 January 2017
- journal article
- case report
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 215 (2), 171-174
- https://doi.org/10.1093/infdis/jiw493
Abstract
A neonate born to an Ebola virus–positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.Keywords
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