Toward Cheap Disposable Sensing Devices for Biological Assays
- 26 July 2010
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Nanotechnology
- Vol. 9 (5), 527-532
- https://doi.org/10.1109/tnano.2010.2060493
Abstract
There is a significant demand for small, portable, and inexpensive analytical devices, which can be used in a wide range of sensing applications (e.g., food monitoring, detection of chemical, biological poisoning agents, environmental monitoring, medical diagnostics, military defense, etc.). Sensors based on organic semiconducting polymers, which are suitable for large-area, low-cost, flexible, and eventually single-use throwaway electronics, provide a unique opportunity in that sense. We report on low-operating voltage organic field-effect transistor devices, which can be used as sensors in electrolytes and liquid media, using a biofunctionalized, biocompatible, regioregular poly(3-hexylthiophene) semiconducting layer. Measurements in electrolytes and complex media relevant for cell analysis have shown that the devices can be directly used as ion-sensitive transducers and are suitable for in vitro biosensing applications. With the demonstration of biocompatible semiconducting polymeric devices, we have overcome a substantial hurdle for the realization of low-cost and mass-produced sensors, opening new possibilities of biological sensing using organic devices.Keywords
This publication has 24 references indexed in Scilit:
- Organic field-effect transistors for biosensing applicationsOrganic Electronics, 2009
- Label-free DNA sensor based on organic thin film transistorsBiosensors and Bioelectronics, 2009
- Water-stable organic transistors and their application in chemical and biological sensorsProceedings of the National Academy of Sciences of the United States of America, 2008
- In vitro evaluation of flexible pH and potassium ion-sensitive organic field effect transistor sensorsApplied Physics Letters, 2008
- Printable polythiophene gas sensor array for low-cost electronic nosesJournal of Applied Physics, 2006
- Interface and gate bias dependence responses of sensing organic thin-film transistorsBiosensors and Bioelectronics, 2005
- Conformable, flexible, large-area networks of pressure and thermal sensors with organic transistor active matrixesProceedings of the National Academy of Sciences of the United States of America, 2005
- Novel array-type gas sensors using conducting polymers, and their performance for gas identificationSensors and Actuators B: Chemical, 2002
- Reproducible fabrication of an array of gas-sensitive chemo-resistors with commercially available polyanilineSensors and Actuators B: Chemical, 2000
- Integrated Optoelectronic Devices Based on Conjugated PolymersScience, 1998