Comparison of Ectoparasites Infestation for Fresh and Saltwater Fishes from Euphrates, and Razzaza Lake, Iraq
- 1 March 1999
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (3), 504-540
- https://doi.org/10.1021/np980406d
Abstract
The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.Keywords
This publication has 68 references indexed in Scilit:
- Chemical Defense in the Zebra Swallowtail Butterfly, Eurytides marcellus, Involving Annonaceous AcetogeninsJournal of Natural Products, 1998
- Modular Approach toward the Construction of the Core Motifs of Annonaceous Acetogenins and Variants ThereofThe Journal of Organic Chemistry, 1998
- Three New Bistetrahydrofuran Acetogenins from the Seeds of Annona spinescensJournal of Natural Products, 1998
- Donnaienin, a New Acetogenin Bearing a Hydroxylated Tetrahydrofuran RingJournal of Natural Products, 1998
- Cherimolin-1, New Selective Inhibitor of the First Energy-Coupling Site of the NADH:Ubiquinone Oxidoreductase (Complex I)Biochemical and Biophysical Research Communications, 1997
- SARs of annonaceous acetogenins in rat liver mitochondriaNatural Toxins, 1996
- Determination of structure-activity relationships of Annonaceous acetogenins by inhibition of oxygen uptake in rat liver mitochondriaChemico-Biological Interactions, 1995
- Mitochondrial respiratory chain inhibitors induce apoptosisFEBS Letters, 1994
- Mode of action of bullatacin: A potent antitumor and pesticidal Annonaceous acetogeninLife Sciences, 1993
- Molecular mode of action of annoninsPesticide Science, 1991