Comparison and reproducibility of ADC measurements in breathhold, respiratory triggered, and free‐breathing diffusion‐weighted MR imaging of the liver
- 28 October 2008
- journal article
- research article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 28 (5), 1141-1148
- https://doi.org/10.1002/jmri.21569
Abstract
To compare and determine the reproducibility of apparent diffusion coefficient (ADC) measurements of the normal liver parenchyma in breathhold, respiratory triggered, and free‐breathing diffusion‐weighted magnetic resonance imaging (DWI). Eleven healthy volunteers underwent three series of DWI. Each DWI series consisted of one breathhold, one respiratory triggered, and two free‐breathing (thick and thin slice acquisition) scans of the liver, at b‐values of 0 and 500 s/mm2. ADCs of the liver parenchyma were compared by using nonparametric tests. Reproducibility was assessed by the Bland–Altman method. Mean ADCs (in 10−3 mm2/sec) in respiratory triggered DWI (2.07–2.27) were significantly higher than mean ADCs in breathhold DWI (1.57–1.62), thick slice free‐breathing DWI (1.62–1.65), and thin slice free‐breathing DWI (1.57–1.66) (P < 0.005). Ranges of mean difference in ADC measurement ± limits of agreement between two scans were −0.02–0.05 ± 0.16–0.24 in breathhold DWI, −0.14–0.20 ± 0.59–0.60 in respiratory triggered DWI, −0.03–0.03 ± 0.20–0.29 in thick slice free‐breathing DWI, and −0.01–0.09 ± 0.21–0.29 in thin slice free‐breathing DWI. ADC measurements of the normal liver parenchyma in respiratory triggered DWI are significantly higher and less reproducible than in breathhold and free‐breathing DWI. J. Magn. Reson. Imaging 2008;28:1141–1148.Keywords
This publication has 18 references indexed in Scilit:
- Functional MRI Evaluation of Tumor Response in Patients with Neuroendocrine Hepatic Metastasis Treated with Transcatheter Arterial ChemoembolizationAmerican Journal of Roentgenology, 2008
- Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesionsEuropean Radiology, 2007
- Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging techniqueEuropean Radiology, 2007
- Diffusion-Weighted MRI for Quantification of Liver Fibrosis: Preliminary ExperienceAmerican Journal of Roentgenology, 2007
- Abdominal MRI advances in the detection of liver tumours and characterisationThe Lancet Oncology, 2007
- Diffusion-weighted MRI in evaluating liver fibrosis: a feasibility study in cirrhotic patientsLa radiologia medica, 2007
- Predicting Response of Colorectal Hepatic Metastasis: Value of Pretreatment Apparent Diffusion CoefficientsAmerican Journal of Roentgenology, 2007
- Diffusion-weighted Imaging of the Liver: Technical Challenges and Prospects for the FutureMagnetic Resonance in Medical Sciences, 2005
- Evaluation of Liver Diffusion Isotropy and Characterization of Focal Hepatic Lesions with Two Single-Shot Echo-planar MR Imaging Sequences: Prospective Study in 66 PatientsRadiology, 2003
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986