Acral myxoinflammatory fibroblastic sarcomas: are they all low‐grade neoplasms?
- 17 August 2007
- journal article
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 35 (2), 186-191
- https://doi.org/10.1111/j.1600-0560.2007.00789.x
Abstract
Acral myxoinflammatory fibroblastic sarcoma (AMIFS) is a low-grade sarcoma that presents mostly in distal extremities of middle-aged patients. The clinicopathologic features, immunohistochemical profile and follow-up data of five cases (three men and two women; age 39-65 years) are presented. The tumors presented as a slow-growing, poorly circumscribed, subcutaneous masses in the hands (three), foot (one) and calf (one), with dermal involvement in two cases. They had myxoid and hyaline stroma with dense acute and chronic inflammation. Spindle cells, large bizarre ganglion-like cells and multivacuolated cells were seen. Variable reactivity in lesional cells were noted for vimentin, Alpha-1-antitrypsin (A1AT), factor XIIIa, CD68, CD95, CD117, Alpha-1-antichymotrypsin (A1ACT), CD34, AE1/3, S-100 protein, EBER, CD63 and CD15. MIB-1 showed 5-30% nuclear labeling. They were negative for cytokeratin AE1/3, smooth muscle actin, CD30, ALK-1, EMA, desmin, CMV, HMB-45 and Melan-A. Follow up ranged from 2 weeks to 95 months (mean 54). One patient was lost to follow up; three underwent excision and one patient had below the knee amputation. Two patients developed metastases (one died of disease), and two patients are alive without evidence of disease. AMIFS are rare tumors that may involve joints and tendons leading to clinical diagnosis of ganglion cyst or tenosynovitis.Keywords
This publication has 13 references indexed in Scilit:
- Myxoinflammatory fibroblastic sarcoma of the neckJournal of Cutaneous Pathology, 2005
- Acral myxoinflammatory fibroblastic sarcoma in FNAB samples: can we distinguish it from other myxoid lesions?Cytopathology, 2003
- Myxoinflammatory fibroblastic sarcoma: A tumor not restricted to acral sitesAnnals of Diagnostic Pathology, 2002
- Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal TumorsThe New England Journal of Medicine, 2002
- Myxoid tumours of soft tissueHistopathology, 1999
- Inflammatory Myxoid Tumor of the Soft Parts with Bizarre Giant CellsPathology - Research and Practice, 1998
- Acral Myxoinflammatory Fibroblastic SarcomaThe American Journal of Surgical Pathology, 1998
- MyxofibrosarcomaThe American Journal of Surgical Pathology, 1996
- Myxoid/Round Cell Liposarcoma of the ExtremitiesThe American Journal of Surgical Pathology, 1996
- Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.Journal of Histochemistry & Cytochemistry, 1981