Polypills for cardiovascular prevention: a step forward?
- 8 October 2013
- journal article
- Published by Springer Science and Business Media LLC in Nature Reviews Cardiology
- Vol. 10 (12), 683-684
- https://doi.org/10.1038/nrcardio.2013.157
Abstract
The effect of a fixed-dose combination drug strategy ('polypill') on patients' adherence to medication was analysed in a series of 2,004 individuals with, or at high risk of, cardiovascular disease in the UMPIRE study. The polypill improved adherence by >20%, but the reduction in blood-pressure and cholesterol levels was modest.Keywords
This publication has 10 references indexed in Scilit:
- Effects of a Fixed-Dose Combination Strategy on Adherence and Risk Factors in Patients With or at High Risk of CVDJAMA, 2013
- The Efficacy and Tolerability of ‘Polypills’: Meta-Analysis of Randomised Controlled TrialsPLOS ONE, 2012
- Maximizing Therapeutic Envelope for Prevention of Cardiovascular Disease: Role of PolypillMount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, 2012
- The Fixed-dose Combination Drug for Secondary Cardiovascular Prevention project: Improving equitable access and adherence to secondary cardiovascular prevention with a fixed-dose combination drug. Study design and objectivesAmerican Heart Journal, 2011
- Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological surveyThe Lancet, 2011
- Multidimensional analysis of treatment adherence in patients with multiple chronic conditions. A cross-sectional study in a tertiary hospitalPatient Education and Counseling, 2010
- Global public health: a scorecardThe Lancet, 2008
- The availability and affordability of selected essential medicines for chronicl diseases in six low- and middle-income countriesBulletin of the World Health Organization, 2007
- Predictors of Adherence With Antihypertensive and Lipid-Lowering TherapyArchives of Internal Medicine, 2005
- A strategy to reduce cardiovascular disease by more than 80%BMJ, 2003