Maximizing Therapeutic Envelope for Prevention of Cardiovascular Disease: Role of Polypill
- 1 November 2012
- journal article
- review article
- Published by Wiley in Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine
- Vol. 79 (6), 683-688
- https://doi.org/10.1002/msj.21355
Abstract
Cardiovascular‐disease prevention is often inadequate due to several factors. Lack of professional adherence to guidelines, unaffordable medication, and lack of patients' adherence to treatment are the most important. It has been suggested that an affordable, fixed‐dose combination drug containing evidence‐based active compounds could improve cardiovascular prevention by improving patients' adherence to treatment. The available evidence suggests that the polypill strategy can achieve this objective and it will gain a place in the therapeutic armamentarium for the prevention of cardiovascular events in patients at high risk. Mt Sinai J Med 79:683–688, 2012. © 2012 Mount Sinai School of MedicineKeywords
This publication has 36 references indexed in Scilit:
- The Fixed-dose Combination Drug for Secondary Cardiovascular Prevention project: Improving equitable access and adherence to secondary cardiovascular prevention with a fixed-dose combination drug. Study design and objectivesAmerican Heart Journal, 2011
- Compuestos de dosis fija en la prevención secundaria de la cardiopatía isquémicaRevista Espanola de Cardiologia, 2011
- An International Randomised Placebo-Controlled Trial of a Four-Component Combination Pill (“Polypill”) in People with Raised Cardiovascular RiskPLOS ONE, 2011
- Projected impact of polypill use among US adults: Medication use, cardiovascular risk reduction, and side effectsAmerican Heart Journal, 2011
- A Polypill for primary prevention of cardiovascular disease: A feasibility study of the World Health OrganizationTrials, 2011
- Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countriesThe Lancet, 2009
- Patient adherence to medical treatment: a review of reviewsBMC Health Services Research, 2007
- Efficacy of Drug Therapy in the Secondary Prevention of Cardiovascular Disease and StrokeThe American Journal of Cardiology, 2007
- The Preventive Polypill — Much Promise, Insufficient EvidenceNew England Journal of Medicine, 2007
- Variations in Patients’ Adherence to Medical RecommendationsMedical Care, 2004