Implants as drug delivery devices for the treatment of eye diseases
Open Access
- 1 September 2010
- journal article
- Published by FapUNIFESP (SciELO) in Brazilian Journal of Pharmaceutical Sciences
- Vol. 46 (3), 585-595
- https://doi.org/10.1590/s1984-82502010000300024
Abstract
The treatment of diseases affecting the posterior segment of the eye is limited by the difficulty in transporting effective doses of drugs to the vitreous, retina, and choroid. Topically applied drugs are poorly absorbed due to the low permeability of the external ocular tissues and tearing. The blood-retina barrier limits drug diffusion from the systemic blood to the posterior segment, thus high doses of drug are needed to maintain therapeutic levels. In addition, systemic side effects are common. Intraocular injections could be an alternative, but the fast flowing blood supply in this region, associated with rapid clearance rates, causes drug concentration to quickly fall below therapeutic levels. To obtain therapeutic levels over longer time periods, polymeric sustained-drug release systems implanted within the vitreous are being studied for the treatment of vitreoretinal disorders. These systems are prepared using different kinds of biodegradable or non-biodegradable polymers. This review aims to demonstrate the main characteristics of these drug delivery implants and their potential for clinical application.Keywords
This publication has 44 references indexed in Scilit:
- Current and future ophthalmic drug delivery systems: A shift to the posterior segmentDrug Discovery Today, 2008
- Intraocular Pressure in Patients With Uveitis Treated With Fluocinolone Acetonide ImplantsAmerican Journal of Ophthalmology, 2007
- Intraocular implants for extended drug delivery: Therapeutic applicationsAdvanced Drug Delivery Reviews, 2006
- PREVENTION OF EXPERIMENTAL PROLIFERATIVE VITREORETINOPATHY WITH A BIODEGRADABLE INTRAVITREAL DRUG DELIVERY SYSTEM OF ALL-TRANS RETINOIC ACIDRetina, 2006
- A retina no século XXIArquivos Brasileiros de Oftalmologia, 2003
- Ocular biocompatibility of a poly(ortho ester) characterized by autocatalyzed degradationJournal of Biomedical Materials Research Part A, 2003
- A viscous bioerodible poly(ortho ester) as a new biomaterial for intraocular applicationJournal of Biomedical Materials Research, 2000
- Biodegradable polymersProgress in Polymer Science, 1998
- Therapeutic applications of implantable drug delivery systemsJournal of Pharmacological and Toxicological Methods, 1998
- Ganciclovir Intraocular ImplantOphthalmology, 1996