PREVENTION OF EXPERIMENTAL PROLIFERATIVE VITREORETINOPATHY WITH A BIODEGRADABLE INTRAVITREAL DRUG DELIVERY SYSTEM OF ALL-TRANS RETINOIC ACID
- 1 February 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Retina
- Vol. 26 (2), 210-213
- https://doi.org/10.1097/00006982-200602000-00015
Abstract
To evaluate the antiproliferative effect of an all-trans retinoic acid (at-RA) drug delivery system (DDS) on experimental proliferative vitreoretinopathy (PVR). PVR was induced in rabbits with core vitrectomy and fibroblast injection. The DDS containing 420 μg, 650 μg, and 1,070 μg of at-RA was implanted into the vitreous of treated groups B, C, and D, respectively. Group A with no DDS and group E with nonmedicated DDS served as controls. The intravitreal at-RA concentration was measured with high-pressure liquid chromatography. The drug toxicity was evaluated histologically. The severity of PVR was significantly reduced in groups C and D but not in groups A, B, and E. The drug release peaked at 6 weeks to 7 weeks. No signs of retinal toxicity were found in the DDS groups. Intravitreal implantation of at-RA DDS appears effective in inhibiting the development of PVR and is well tolerated in rabbit eyes.Keywords
This publication has 6 references indexed in Scilit:
- Formation of proliferative vitreoretinopathy in primary rhegmatogenous retinal detachment.Documenta Ophthalmologica, 2000
- Factors modulating the effect of retinoids on cultured retinal pigment epithelial cell proliferationCurrent Eye Research, 1992
- Intraocular Daunorubicin for the Treatment and Prophylaxis of Traumatic Proliferative VitreoretinopathyAmerican Journal of Ophthalmology, 1987
- The Effect of Triamcinolone Acetonide on a Refined Experimental Model of Proliferative VitreoretinopathyAmerican Journal of Ophthalmology, 1985
- Proliferative VitreoretinopathyAmerican Journal of Ophthalmology, 1985
- 5-fluorouracil: New Applications in Complicated Retinal Detachment for an Established AntimetaboliteOphthalmology, 1984