Bioavailability of Polyphenol Liposomes: A Challenge Ahead
Open Access
- 17 September 2013
- journal article
- review article
- Published by MDPI AG in Pharmaceutics
- Vol. 5 (3), 457-471
- https://doi.org/10.3390/pharmaceutics5030457
Abstract
Dietary polyphenols, including flavonoids, have long been recognized as a source of important molecules involved in the prevention of several diseases, including cancer. However, because of their poor bioavailability, polyphenols remain difficult to be employed clinically. Over the past few years, a renewed interest has been devoted to the use of liposomes as carriers aimed at increasing the bioavailability and, hence, the therapeutic benefits of polyphenols. In this paper, we review the causes of the poor bioavailability of polyphenols and concentrate on their liposomal formulations, which offer a means of improving their pharmacokinetics and pharmacodynamics. The problems linked to their development and their potential therapeutic advantages are reviewed. Future directions for liposomal polyphenol development are suggested.This publication has 73 references indexed in Scilit:
- Using Liposomes as Carriers for Polyphenolic Compounds: The Case of Trans-ResveratrolPLOS ONE, 2012
- Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell deathInternational Journal of Nanomedicine, 2012
- Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacyInternational Journal of Nanomedicine, 2011
- Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases—Safety, Pharmacokinetics, and PharmacodynamicsCancer Prevention Research, 2011
- Advanced Drug Delivery Systems of Curcumin for Cancer ChemopreventionCancer Prevention Research, 2011
- Chemistry and Biochemistry of Dietary PolyphenolsNutrients, 2010
- Liposome Technology for Industrial PurposesJournal of Drug Delivery, 2010
- Bioavailability of the Polyphenols: Status and ControversiesInternational Journal of Molecular Sciences, 2010
- Curcumin―The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention and TreatmentToxins, 2010
- Structure-antioxidant activity relationships of flavonoids and phenolic acidsFree Radical Biology & Medicine, 1996