Curcumin―The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention and Treatment
Open Access
- 21 January 2010
- Vol. 2 (1), 128-162
- https://doi.org/10.3390/toxins2010128
Abstract
As cancer is a multifactor disease, it may require treatment with compounds able to target multiple intracellular components. We summarize here how curcumin is able to modulate many components of intracellular signaling pathways implicated in inflammation, cell proliferation and invasion and to induce genetic modulations eventually leading to tumor cell death. Clinical applications of this natural compound were initially limited by its low solubility and bioavailability in both plasma and tissues but combination with adjuvant and delivery vehicles was reported to largely improve bio-availability of curcumin. Moreover, curcumin was reported to act in synergism with several natural compounds or synthetic agents commonly used in chemotherapy. Based on this, curcumin could thus be considered as a good candidate for cancer prevention and treatment when used alone or in combination with other conventional treatments.Keywords
This publication has 212 references indexed in Scilit:
- RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivoBiochemical Pharmacology, 2010
- RETRACTED: Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkersBiochemical Pharmacology, 2010
- Harnessing the fruits of nature for the development of multi-targeted cancer therapeuticsCancer Treatment Reviews, 2009
- Targeting breast stem cells with the cancer preventive compounds curcumin and piperineBreast Cancer Research and Treatment, 2009
- Role and regulation of autophagy in cancerBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
- Inflammation and cancer: how friendly is the relationship for cancer patients?Current Opinion in Pharmacology, 2009
- Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studiesBioorganic & Medicinal Chemistry, 2009
- Targeting the telosome: Therapeutic implicationsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)Free Radical Biology & Medicine, 2007
- The Wnt-dependent signaling pathways as target in oncology drug discoveryInvestigational New Drugs, 2006