Practical implications of liver and heart iron load assessment by T2*‐MRI in children and adults with transfusion‐dependent anemias
Open Access
- 16 May 2008
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 83 (10), 781-783
- https://doi.org/10.1002/ajh.21221
Abstract
This study examined the relationship between hepatic and myocardial iron concentration, assessed by T2*‐MRI in 66 patients (3–82 years) with transfusion‐dependent anemias and thalassemia intermedia, to determine whether hepatic iron levels alone suffice for chelation adjustments. We found a poor correlation between hepatic and myocardial iron (r = 0.10, P = 0.43) and identified a subgroup (14%) with increased myocardial iron without a matched degree of hepatic hemosiderosis. Left ventricular ejection fraction was insensitive for detecting elevated myocardial iron. These findings were present in both adult and pediatric patients. We recommend therapeutic monitoring of iron burden by evaluation of both liver and myocardial iron with T2*‐MRI. Am. J. Hematol., 2008.This publication has 15 references indexed in Scilit:
- Myocardial tissue characterization and the role of chronic anemia in sickle cell cardiomyopathyJournal of Magnetic Resonance Imaging, 2007
- MRI detects myocardial iron in the human heartMagnetic Resonance in Medicine, 2006
- Intercentre Reproducibility of Magnetic Resonance T2* Measurements of Myocardial Iron in ThalassaemiaThe International Journal of Cardiovascular Imaging, 2005
- A comparison of magnetic resonance imaging and cardiac biopsy in the evaluation of heart iron overload in patients with β‐thalassemia majorEuropean Journal of Haematology, 2005
- Cardiac Iron Determines Cardiac T2*, T2, and T1 in the Gerbil Model of Iron CardiomyopathyCirculation, 2005
- Myocardial biopsy and T2* magnetic resonance in heart failure due to thalassaemiaBritish Journal of Haematology, 2004
- Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonanceBritish Journal of Haematology, 2004
- Myocardial iron loading in transfusion-dependent thalassemia and sickle cell diseaseBlood, 2004
- Interscanner reproducibility of cardiovascular magnetic resonance T2* measurements of tissue iron in thalassemiaJournal of Magnetic Resonance Imaging, 2003
- Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overloadEuropean Heart Journal, 2001