MRI detects myocardial iron in the human heart
Open Access
- 3 August 2006
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 56 (3), 681-686
- https://doi.org/10.1002/mrm.20981
Abstract
Iron‐induced cardiac dysfunction is a leading cause of death in transfusion‐dependent anemia. MRI relaxation rates R2(1/T2) and R(1/T) accurately predict liver iron concentration, but their ability to predict cardiac iron has been challenged by some investigators. Studies in animal models support similar R2 and R behavior with heart and liver iron, but human studies are lacking. To determine the relationship between MRI relaxivities and cardiac iron, regional variations in R2 and R were compared with iron distribution in one freshly deceased, unfixed, iron‐loaded heart. R2 and R were proportionally related to regional iron concentrations and highly concordant with one another within the interventricular septum. A comparison of postmortem and in vitro measurements supports the notion that cardiac R should be assessed in the septum rather than the whole heart. These data, along with measurements from controls, provide bounds on MRI‐iron calibration curves in human heart and further support the clinical use of cardiac MRI in iron‐overload syndromes. Magn Reson Med, 2006.Keywords
This publication has 35 references indexed in Scilit:
- Child and family outcomes of a long-term nurse home visitation programme: a randomised controlled trialArchives of Disease in Childhood, 2011
- Programs for parents of infants and toddlers: recent evidence from randomized trialsJournal of Child Psychology and Psychiatry, 2007
- Role of home visiting in improving parenting and health in families at risk of abuse and neglect: results of a multicentre randomised controlled trial and economic evaluationArchives of Disease in Childhood, 2007
- Improved R2* measurements in myocardial iron overloadJournal of Magnetic Resonance Imaging, 2005
- A comparison of magnetic resonance imaging and cardiac biopsy in the evaluation of heart iron overload in patients with β‐thalassemia majorEuropean Journal of Haematology, 2005
- Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonanceBlood, 2005
- Is it time to rethink Healthy Start/Healthy Families?Child Abuse & Neglect, 2004
- Randomized trial of a statewide home visiting program: impact in preventing child abuse and neglectChild Abuse & Neglect, 2004
- SAS® System for Mixed ModelsTechnometrics, 1997
- Iron in the heart: Etiology and clinical significanceAmerican Journal Of Medicine, 1971