Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma
Open Access
- 12 April 2012
- journal article
- Published by American Society of Hematology in Blood
- Vol. 119 (15), 3534-3538
- https://doi.org/10.1182/blood-2011-12-396457
Abstract
Tumor-derived galectin-1 (Gal-1), a β-galactoside–binding S-type lectin, has been shown to encourage T-cell death and promote T cell–mediated tumor immune escape. In this report, we show that patients with leukemic cutaneous T-cell lymphomas, known to have limited complexity of their T-cell repertoires, have a predominant T helper type-2 (Th2) cytokine profile and significantly elevated plasma levels of Gal-1 compared with healthy controls. Circulating clonal malignant T cells were a major source of Gal-1. The conditioned supernatant of cultured malignant T cells induced a β-galactoside–dependent inhibition of normal T-cell proliferation and a Th2 skewing of cytokine production. These data implicate Gal-1 in development of the Th2 phenotype in patients with advanced-stage cutaneous T-cell lymphoma and highlight the Gal-1–Gal-1 ligand axis as a potential therapeutic target for enhancing antitumor immune responses.This publication has 24 references indexed in Scilit:
- Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 ExpressionThe Journal of Immunology, 2012
- Galectin-1 research in T cell immunity: Past, present and futureClinical Immunology, 2012
- Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor ImmunityJournal of Investigative Dermatology, 2012
- Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct IncorporationOnline Journal of Public Health Informatics, 2011
- Development of a Nascent Galectin-1 Chimeric Molecule for Studying the Role of Leukocyte Galectin-1 Ligands and Immune Disease ModulationThe Journal of Immunology, 2010
- Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphomaArchiv für dermatologische Forschung, 2010
- Galectin-1 mediated suppression of Epstein-Barr virus–specific T-cell immunity in classic Hodgkin lymphomaBlood, 2007
- The AP1-dependent secretion of galectin-1 by Reed–Sternberg cells fosters immune privilege in classical Hodgkin lymphomaProceedings of the National Academy of Sciences of the United States of America, 2007
- Expression of Interleukin-18 and Caspase-1 in Cutaneous T-Cell LymphomaClinical Cancer Research, 2006
- Galectin fingerprinting by immuno- and lectin histochemistry in cutaneous lymphomaZeitschrift für Krebsforschung und Klinische Onkologie, 2002