Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
- 1 February 1989
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 337 (6208), 615-620
- https://doi.org/10.1038/337615a0
Abstract
The crystal structure of the protease of the human immunodeficiency virus type (HIV-1), which releases structural proteins and enzymes from viral polyprotein products, has been determined to 3 A resolution. Large regions of the protease dimer, including the active site, have structural homology to the family of microbial aspartyl proteases. The structure suggests a mechanism for the autoproteolytic release of protease and a role in the control of virus maturation.Keywords
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