Breast cancer stem cells, cytokine networks, and the tumor microenvironment
Open Access
- 3 October 2011
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 121 (10), 3804-3809
- https://doi.org/10.1172/jci57099
Abstract
Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment — including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells — through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.Keywords
This publication has 106 references indexed in Scilit:
- Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone CellsCancer Cell, 2011
- Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin LymphomaCell, 2010
- STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to CancerMolecular Cell, 2010
- Interleukin-6 in bone metastasis and cancer progressionEuropean Journal of Cancer, 2010
- An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell TransformationCell, 2009
- Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant MetastasisCancer Cell, 2009
- ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical OutcomeCell Stem Cell, 2007
- Hypoxia-Inducible Factors, Stem Cells, and CancerCell, 2007
- Inflammation and cancerNature, 2002
- Induction of angiogenesis during the transition from hyperplasia to neoplasiaNature, 1989