Effect of Extreme Cold Exposure on Adrenocortical Function in the Unanesthetized Dog
- 1 May 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 185 (2), 239-242
- https://doi.org/10.1152/ajplegacy.1956.185.2.239
Abstract
Unanesthetized dogs with polyethylene cannulas in the right lumboadrenal vein were subjected to environmental temperatures of –46 to –50°C for 2–28 hours and –75 to –79°C for 4–5 hours. Adrenal venous blood samples were collected prior to, and during the periods of cold exposure, and analyzed for 17-hydroxycorticosteroids. In both temperature ranges, a marked increase in adrenal steroid output occurred soon after the onset of exposure in the 10 dogs studied. In 9 of the 10 animals, this response persisted for 1–3 hours after which adrenal steroid secretion returned to control, pre-exposure levels, despite continued cold exposure. The intravenous administration of 40 iu of ACTH produced a subsequent increase in adrenal 17-hydroxycorticosteroid output. Healthy dogs exposed to temperatures of –47°C for 28 hours and –79°C for 5 hours did not become hypothermic.Keywords
This publication has 2 references indexed in Scilit:
- A METHOD FOR THE DETERMINATION OF 17-HYDROXYCORTICOSTEROIDS IN BLOOD: 17-HYDROXYCORTICOSTERONE IN THE PERIPHERAL CIRCULATION*Journal of Clinical Endocrinology & Metabolism, 1952
- THE PITUITARY‐ADRENAL SYSTEMAnnals of the New York Academy of Sciences, 1949