Platelet size in patients with chronic airflow obstruction with and without hypoxaemia.
- 1 January 1988
- Vol. 43 (1), 61-64
- https://doi.org/10.1136/thx.43.1.61
Abstract
Platelet size, expressed as mean platelet volume, was estimated in 35 patients with chronic airflow obstruction and a wide range of arterial oxygen tension (PaO2) values. In these patients there was a negative correlation between MPV and PaO2 (r = -0.70). Mean platelet volume was greater (9.41 (0.86) fl) in 20 patients with an arterial PaO2 of 8 kPa (60 mm Hg) or less than in 18 normal subjects (8.21 (0.63) fl; p less than 0.001). After 24 hours of supplemental oxygen treatment there was a small fall in mean platelet volume, from 9.47 (1.06) to 8.96 (0.8) fl (p less than 0.05) in 12 hypoxaemic patients (PaO2 breathing air less than or equal to 8 kPa) but no change in nine non-hypoxaemic patients. Larger platelets are considered to be haemostatically more active, leading to abnormal platelet function, which may contribute to the development of pulmonary vascular damage in chronic hypoxaemia. Supplemental oxygen may partially reverse these changes by modifying platelet size and activity.This publication has 16 references indexed in Scilit:
- Changes in volume and density of platelets in myocardial infarction.BMJ, 1983
- Platelet size in myocardial infarction.BMJ, 1983
- ABNORMAL INTRAPULMONARY PLATELET PRODUCTION: A POSSIBLE CAUSE OF VASCULAR AND LUNG DISEASEThe Lancet, 1983
- Platelet size as a determinant of platelet function.1983
- Evidence for a theory of physical fragmentation of megakaryocytes, implying that all platelets are produced in the pulmonary circulationThrombosis Research, 1982
- The Platelet Count and Mean Platelet VolumeBritish Journal of Haematology, 1981
- Platelet Density and Size: the Interpretation of HeterogeneityBritish Journal of Haematology, 1976
- Heterogeneity of human PlateletsJCI Insight, 1969
- Heterogeneity of human plateletsJCI Insight, 1969
- Platelet Volume and Shape in Relation to Aggregation and AdhesionBritish Journal of Haematology, 1967