Platelet size in myocardial infarction.
- 13 August 1983
- Vol. 287 (6390), 449-451
- https://doi.org/10.1136/bmj.287.6390.449
Abstract
The mean platelet volume and platelet count were measured serially in 100 patients soon after myocardial infarction and again at a follow up clinic about seven weeks later. The results were compared with those in age matched controls. The mean platelet volume after infarction (mean 9.07 fl (SE 0.08] was significantly greater than in the controls (8.32 fl (SE 0.07); p less than 0.001), and was still raised at the follow up clinic (8.69 fl (SE 0.10); p less than 0.01). The mean platelet count on admission (275 X 10(9)/1 (SE 7] was significantly lower than in the control group (295 X 10(9)/1 (SE 5); p less than 0.05) and fell significantly during admission, with a mean change of -36 X 10(9)/1 (95% confidence limits -26, -45; p less than 0.01). At the follow up clinic the platelet count had risen to a level not significantly different from the admission value. As larger platelets are haemostatically more active, the finding of an increased mean platelet volume after myocardial infarction provides further evidence that abnormal platelet behaviour may be implicated in the process of infarction.Keywords
This publication has 21 references indexed in Scilit:
- The Coulter Counter Model S Plus- the shape of things to comeClinical and Laboratory Haematology, 2008
- Platelets in the prediction of thrombotic riskAtherosclerosis, 1982
- Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume.BMJ, 1982
- Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and functionBritish Journal of Haematology, 1982
- Platelet-release reaction in myocardial infarction.BMJ, 1980
- Platelet function studies in coronary artery disease: V. Evidence for enhanced platelet microthrombus formation activity in acute myocardial infarctionThe American Journal of Cardiology, 1979
- Platelet Density and Size: the Interpretation of HeterogeneityBritish Journal of Haematology, 1976
- Heterogeneity of human plateletsJCI Insight, 1969
- The effect of platelet age on platelet adherence to collagenJCI Insight, 1968
- Platelet Volume and Shape in Relation to Aggregation and AdhesionBritish Journal of Haematology, 1967