Journey of Mesenchymal Stem Cells for Homing: Strategies to Enhance Efficacy and Safety of Stem Cell Therapy
Open Access
- 13 June 2012
- journal article
- review article
- Published by Hindawi Limited in Stem Cells International
- Vol. 2012, 1-11
- https://doi.org/10.1155/2012/342968
Abstract
Human mesenchymal stem cells (MSCs) communicate with other cells in the human body and appear to “home” to areas of injury in response to signals of cellular damage, known as homing signals. This review of the state of current research on homing of MSCs suggests that favorable cellular conditions and thein vivoenvironment facilitate and are required for the migration of MSCs to the site of insult or injuryin vivo. We review the current understanding of MSC migration and discuss strategies for enhancing both the environmental and cellular conditions that give rise to effective homing of MSCs. This may allow MSCs to quickly find and migrate to injured tissues, where they may best exert clinical benefits resulting from improved homing and the presence of increased numbers of MSCs.Keywords
This publication has 138 references indexed in Scilit:
- Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria modelNature Communications, 2012
- Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-αNature Medicine, 2011
- Concise Review: Hitting the Right Spot with Mesenchymal Stromal CellsThe International Journal of Cell Cloning, 2010
- Mesenchymal stem cell therapy: Two steps forward, one step backTrends in Molecular Medicine, 2010
- Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult ratsBrain Research, 2008
- Homing and engraftment of progenitor cells: A prerequisite for cell therapyJournal of Molecular and Cellular Cardiology, 2008
- Mesenchymal Stem Cells: Revisiting History, Concepts, and AssaysCell Stem Cell, 2008
- Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/ scid miceProceedings of the National Academy of Sciences of the United States of America, 2006
- Intravenous administration of glial cell line‐derived neurotrophic factor gene‐modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult ratJournal of Neuroscience Research, 2006
- Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcomaThe Journal of Experimental Medicine, 2006