Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity
- 5 January 2015
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Drug Metabolism & Toxicology
- Vol. 11 (4), 589-599
- https://doi.org/10.1517/17425255.2015.1020295
Abstract
Fluorine's unique physicochemical properties make it a key element for incorporation into pharmacologically active compounds. Its presence in a drug can alter a number of characteristics that affect ADME-Tox, which has prompted efforts at improving synthetic fluorination procedures.Keywords
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