Fluorine in medicinal chemistry
Top Cited Papers
- 13 December 2007
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 37 (2), 320-330
- https://doi.org/10.1039/b610213c
Abstract
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.Keywords
This publication has 38 references indexed in Scilit:
- Pharmacokinetics and Metabolism in Drug DesignMethods and Principles in Medicinal Chemistry, 2006
- Endocrine treatment options for advanced breast cancer – the role of fulvestrantEuropean Journal of Cancer, 2005
- Structure?Activity Relationships for Three Macrolide Antibiotics in Haemophilus influenzaeCurrent Microbiology, 2004
- Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysisEuropean Journal of Pharmacology, 2003
- Electronic and resonance effects on the lonization of structural analogues of efavirenzAAPS PharmSci, 2001
- Antimicrobial activity and postantibiotic effect of flurithromycin against Helicobacter pylori strainsInternational Journal of Antimicrobial Agents, 2001
- EfavirenzPharmacoEconomics, 2001
- EfavirenzDrugs, 1998
- Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publicationLife Sciences, 1995
- Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory CompoundsNature, 1957