Immune Complex-Mediated Enhancement of Secondary Antibody Responses
- 1 June 2010
- journal article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 184 (11), 6293-6298
- https://doi.org/10.4049/jimmunol.0902530
Abstract
Immunologic memory is a hallmark of the vertebrate immune system. The first antigenic exposure leads to a slow and modest immune response, whereas repeated exposure, even many years later, leads to a rapid and exaggerated response that is two to three orders of magnitude greater than the primary. In the case of humoral immunity, the increased efficacy of recall responses is due to the production of amplified levels of Ag-specific Ab, as well as the accelerated kinetics of their production. Current thinking suggests that this is due to selective activation of long-lived, Ag-specific memory B cells. A downside of restricting secondary responses solely to memory cells is that the repertoire of the memory B cell pool remains static while pathogens continue to evolve. In this study, we propose that during secondary responses, naive Ag-specific B cells participate alongside memory cells. We show that immune complexes formed in vivo between the Ag and pre-existing Abs from the primary response activate these naive B cells, inducing them to respond with accelerated kinetics and increased magnitude. Thus, the continued recruitment of new B cell clones after each antigenic exposure enables the immune system to stay abreast of rapidly changing pathogens.Keywords
This publication has 30 references indexed in Scilit:
- Dynamics of the Interaction of Human IgG Subtype Immune Complexes with Cells Expressing R and H Allelic Forms of a Low-Affinity Fcγ Receptor CD32AThe Journal of Immunology, 2009
- New insights into the regulation of human B-cell differentiationTrends in Immunology, 2009
- Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fcγ receptors and can be effectively blocked by decoy Fcγ receptorsBlood, 2008
- The role of integrins and coreceptors in refining thresholds for B‐cell responsesImmunological Reviews, 2007
- ANTIGEN-SPECIFIC MEMORY B CELL DEVELOPMENTAnnual Review of Immunology, 2005
- Depletion of Complement Has Distinct Effects on the Primary and Secondary Antibody Responses to a Conjugate of Pneumococcal Serotype 14 Capsular Polysaccharide and a T-Cell-Dependent Protein CarrierInfection and Immunity, 2005
- The complement system in B cell regulationMolecular Immunology, 2004
- Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-xL Transgenic MiceThe Journal of Experimental Medicine, 1999
- Synovial IgG rheumatoid factors show evidence of an antigen‐driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factorsEuropean Journal of Immunology, 1993
- A B cell population that dominates the primary response to influenza virus hemagglutinin does not participate in the memory responseEuropean Journal of Immunology, 1991