The role of integrins and coreceptors in refining thresholds for B‐cell responses
- 9 July 2007
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 218 (1), 197-213
- https://doi.org/10.1111/j.1600-065x.2007.00540.x
Abstract
Despite compelling evidence that a large proportion of antigens encountered in vivo by B cells are membrane bound, the general view is that B cells are mainly activated by soluble antigens. This notion may have been biased somewhat over the years because the high affinity of the B-cell receptor (BCR) for soluble intact ligands allows efficient B-cell stimulation in vitro. In vivo, however, even soluble antigens are likely to be deposited on the surface of antigen-presenting cells, either by complement or Fc receptors in the form of immune complexes, thus becoming more potent stimulators of B-cell activation. In this framework, the BCR works in a complex environment of integrins and coreceptors, as well as the B-cell cytoskeleton. Over the last few years, we have focused on B-cell membrane-bound antigen recognition. Here, we discuss some of our findings in the context of what is currently known in this exciting new field.Keywords
This publication has 138 references indexed in Scilit:
- In vivo imaging of germinal centres reveals a dynamic open structureNature, 2007
- T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation ClusterImmunity, 2006
- Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic CellsScience, 2006
- Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76Nature Immunology, 2005
- Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signalingThe Journal of Experimental Medicine, 2005
- Visualizing dendritic cell networks in vivoNature Immunology, 2004
- A Conduit System Distributes Chemokines and Small Blood-borne Molecules through the Splenic White PulpThe Journal of Experimental Medicine, 2003
- Direct observation of ligand recognition by T cellsNature, 2002
- T cell receptor ligation induces the formation of dynamically regulated signaling assembliesThe Journal of cell biology, 2002
- Blood Dendritic Cells Interact with Splenic Marginal Zone B Cells to Initiate T-Independent Immune ResponsesImmunity, 2002