Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury
Open Access
- 9 July 2007
- journal article
- Published by Springer Science and Business Media LLC in Respiratory Research
- Vol. 8 (1), 50
- https://doi.org/10.1186/1465-9921-8-50
Abstract
Bone marrow-derived progenitors for both epithelial and endothelial cells have been observed in the lung. Besides mature endothelial cells (EC) that compose the adult vasculature, endothelial progenitor cells (EPC) are supposed to be released from the bone marrow into the peripheral blood after stimulation by distinct inflammatory injuries. Homing of ex vivo generated bone marrow-derived EPC into the injured lung has not been investigated so far. We therefore tested the hypothesis whether homing of EPC in damaged lung tissue occurs after intravenous administration.Keywords
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