Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow
- 1 December 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 290 (5497), 1779-1782
- https://doi.org/10.1126/science.290.5497.1779
Abstract
Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow–derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.This publication has 38 references indexed in Scilit:
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