Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy
Open Access
- 13 November 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 2 (1), srep00847
- https://doi.org/10.1038/srep00847
Abstract
Nanoparticle exposure in pregnancy may result in placental damage and fetotoxicity; however, the factors that determine fetal nanoparticle exposure are unclear. Here we have assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. We determined the placental and fetal uptake of 13 nm gold nanoparticles with different surface modifications (ferritin, PEG and citrate) following intravenous administration at E5.5-15.5. We showed that prior to E11.5, all tested nanoparticles could be visualized and detected in fetal tissues in significant amounts; however, fetal gold levels declined dramatically post-E11.5. In contrast, Au-nanoparticle accumulation in the extraembryonic tissues (EET) increased 6–15 fold with gestational age. Fetal and EET accumulation of ferritin- and PEG-modified nanoparticles was considerably greater than citrate-capped nanoparticles. No signs of toxicity were observed. Fetal exposure to nanoparticles in murine pregnancy is, therefore, influenced by both stage of embryonic/placental maturation and nanoparticle surface composition.This publication has 45 references indexed in Scilit:
- Serum ferritin: Past, present and futureBiochimica et Biophysica Acta (BBA) - General Subjects, 2010
- Barrier Capacity of Human Placenta for Nanosized MaterialsEnvironmental Health Perspectives, 2010
- Protein‐Based Nanomedicine Platforms for Drug DeliverySmall, 2009
- Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouseParticle and Fibre Toxicology, 2009
- Factors Affecting the Clearance and Biodistribution of Polymeric NanoparticlesMolecular Pharmaceutics, 2008
- Kupffer cells are central in the removal of nanoparticles from the organismParticle and Fibre Toxicology, 2007
- Human Early Placental Development: Potential Roles of the Endometrial GlandsPlacenta, 2007
- The Comparative Immunotoxicity of Five Selected Compounds Following Developmental or Adult ExposureJournal of Toxicology and Environmental Health, Part B, 2006
- Drug Transfer and Metabolism by the Human PlacentaClinical Pharmacokinetics, 2004
- Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivoFEBS Letters, 1996